Correlation Between Receptor Status and Presence of Axillary Lymph Node Metastasis in Breast Cancer in Kenya
Marilynn Omondi Akinyi, Kiptoon Dan, Ojuka Kinyuru Daniel, Walong Edwin
School of Medicine, University of Nairobi
Correspondence to: Dr. Marilynn Akinyi Omondi, Department of Surgery, University of Nairobi, PO Box 19676–00202, Nairobi;
email: marokinyi@gmail.com

 Abstract

Background: Breast cancer survival is linked to early detection, and timely and appropriate treatment. Survival depends on the stage and biological behaviour of the tumour. It is unclear how different molecular subtypes impact on axillary node involvement. Objective: This study sought to determine the correlation between hormonal receptor status with axillary nodal status in breast carcinoma. Methodology: A cross sectional study was carried out at Kenyatta National Hospital surgical wards and histopathology laboratory. Patients with a histological diagnosis of breast cancer, scheduled to undergo a modified radical mastectomy, were recruited. Data collected included age at diagnosis, parity, menopausal status, clinical examination findings, stage of the disease clinically and pathologically, and hormonal receptor status. Data were analyzed using SPSS version 21.0. Results: We enrolled 79 women with invasive breast carcinoma. Mean age was 48 (SD=14.5) years. Most (48.1%) presented with stage III tumour. Most tumours (58.2%) were luminal A. Correlation between molecular type and nodal involvement was not significant. Luminal B was significantly present in those above 50 years (p=0.011). Conclusion: The most common molecular type of breast cancer was luminal A, but luminal B disease which was prevalent in women more than 50 years old was the only molecular subtype that had a positive correlation with axillary nodal status.

Key words: Breast cancer, Axillary lymph nodes, Molecular subtypes, Hormonal receptor status, HER-2 status

Ann Afr Surg. 2019; 16(2):51–54

DOI:http://dx.doi.org/10.4314/aas.v16i2.2

Conflicts of Interest: None

Funding: None

© 2019 Author. This work is licensed under the Creative Commons Attribution 4.0 International License.

ssk_logo.png

The Annals of African Surgery is the official publication of the Surgical Society of Kenya.

 

All content copyright © 2020 Annals of African Surgery.

ISSN (print): 1999-9674; ISSN (online): 2523-0816

Main Office Location: Menelik Medical Centre, Menelik Road, off Ngong Road, Nairobi. First floor.

Telephone: +254715260499

Email: info@annalsofafricansurgery.com.

 

The content on this site is intended for health professionals. Advertisements on this site do not constitute a guarantee or endorsement by the journal, Association, or publisher of the quality or value of such product or of the claims made for it by its manufacturer.

70.png
69.jpg
hinari_header_en.png
  • Twitter
  • Facebook Social Icon
  • LinkedIn