Combination Drug Therapy for Benign Prostatic Hyperplasia (BPH)

Author Information

Oliech J.S. FRCS, Affiliation: Department of Surgery, University of Nairobi.

Corresponding author:

Dr. Oliech J.S., P.O Box 30197-00100, Nairobi. E-mail: jsoliech@yahoo.com

Abstract

Background: The incidence of benign prostatic hyperplasia peaks 80% in old age. Bothersome symptoms and progression to acute urinary retention and need for surgery are important concerns. Apha blockers and 5 alpha reductase inhibitors address these to variable extents. This article reviews the current place of medical therapy in the treatment of BPH, with a focus on combination therapy.

Data Source: A medline literature search was performed to identify original studies including global multi-center trials and reviews on the subject.

Conclusion: BPH symptom reduction and shrinkage of prostate size by the use of a combination of alpha adrenergic uroselective blocker (Tamsulosin) and 5 alpha iso-enzyme inhibitor (Dutasteride) is a first option of therapy in the management of BPH especially in those cases that are surgical risks with the category of mild to moderate prostate symptom scores.

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