Potential of the Pentacam in screening for narrow angles in patients with Chronic Angle Closure Glaucoma

Seth Lartey1,2, Abdul-Kabir Mohammed3, Emmanuel Appiagyei2, Kojo O. Akuffo3

1 EENT Department, Kwame Nkrumah University of Science and Technology

2 Eye department, Komfo Anokye Teaching Hospital

3 Department of Optometry, Kwame Nkrumah University of Science and Technology

Correspondence to:

Seth Lartey, Department of Eye Ear Nose and Throat, Nkrumah University of Science and Technology, Kumasi, Ghana.

Email: sylartey@yahoo.com

Abstract

Background: Chronic angle closure glaucoma (CACG) is a visually destructive disease. Effective management of CACG requires identification of eyes with narrow angle. Objective: To compare pentacam with gonioscopy in detecting narrow angles in eyes with CACG.

Methods: We enrolled 101 eyes with glaucoma. Gonioscopy was performed on all eyes. Using Shaffer’s grading, subjects were classified into angle closure and open angle. Anterior chamber volume (ACV) and anterior chamber depth (ACD) were measured with the pentacam. Receiver operating curve (ROC) was constructed for each parameter and the area under the curve (AUC) was calculated. Results: Ten eyes (9.9%) were classified as angle closure on gonioscopy. For detection of narrow angles, ACV (AUC 0.956; 95% confidence interval (CI) 0.894 – 0.987) performed similar to ACD (AUC = 0.930, p = 0.33). Using a cut off of 102mm3, ACV had 100% sensitivity and 88.5% specificity for detecting narrow angles in chronic angle closure glaucoma patients. With an ACV cutoff of 102mm3, the PPV for detecting angle closure was 48.9% (95% CI, 34.8-68.2), while the NPV was 100% (94.1% - 100%), using 9.9% prevalence of angle closure from this study. Conclusion: ACV and ACD measured by the pentacam has the potential to determine narrow angles in eyes with CACG.

 

Keywords: Chronic angle closure glaucoma, Pentacam HR, Anterior chamber volume, Gonioscopy.

Ann Afr Surg. ****; **(*):***

DOI: http://dx.doi.org/10.4314/aas.v*****

Conflicts of Interest: None

Funding: None

© 2020 Author. This work is licensed under the Creative Commons Attribution 4.0 International License.

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